Overview
Burkitt lymphoma is highly aggressive, c-MYC translocation.
Symptoms
- •Jaw swelling
- •Abdominal mass
- •B symptoms
- •CNS involvement
Diagnosis
- ✓Biopsy
- ✓IHC (Ki-67 ~100%)
- ✓t(8;14)
- ✓PET-CT
Treatments
- →Intensive chemotherapy (CODOX-M/IVAC)
- →Rituximab
- →CNS prophylaxis
Risk Factors
⚠️EBV
⚠️HIV
⚠️Malaria (endemic)
Key Facts
- ℹ️>90% cure rate in children
- ℹ️Endemic (EBV), sporadic, immunodeficiency
ICD-10: C83.7 | Prevalence: nadir
Last updated: 11/9/2025