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Celiac Disease

Autoimmune Disease

Overview

Celiac disease is autoimmune reaction to gluten causing small bowel villous atrophy.

Symptoms

  • Diarrhea
  • Failure to thrive
  • Bloating
  • Dermatitis herpetiformis

Diagnosis

  • tTG-IgA + total IgA
  • Duodenal biopsy
  • HLA-DQ2/DQ8

Treatments

  • Strict gluten-free diet
  • Nutritional support
  • Monitor growth/bone

Risk Factors

⚠️HLA-DQ2/DQ8
⚠️Family history
⚠️T1DM
⚠️Down syndrome

Key Facts

  • ℹ️1% prevalence
  • ℹ️Associated with T1DM, thyroid

ICD-10: K90.0 | Prevalence: yaygın

Last updated: 11/9/2025