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Familial Adenomatous Polyposis (FAP)

Colorectal Cancer

Overview

FAP is an inherited condition with hundreds of colon polyps.

Symptoms

  • Rectal bleeding
  • Anemia
  • Diarrhea

Diagnosis

  • Colonoscopy
  • Genetic testing (APC)

Treatments

  • Prophylactic colectomy
  • Sulindac
  • Annual surveillance

Risk Factors

⚠️APC gene mutation

Key Facts

  • ℹ️100% risk of cancer if untreated
  • ℹ️Screen family members

ICD-10: D12.6 | Prevalence: nadir

Last updated: 11/9/2025