Overview
GIST is a sarcoma of the GI tract, driven by KIT or PDGFRA mutations.
Symptoms
- •Abdominal pain
- •GI bleeding
- •Early satiety
- •Mass
Diagnosis
- ✓CT abdomen
- ✓Endoscopy
- ✓Biopsy
- ✓KIT/PDGFRA testing
Treatments
- →Surgical resection
- →Imatinib (Gleevec)
- →Sunitinib
- →Regorafenib
Risk Factors
⚠️Neurofibromatosis type 1
⚠️Familial GIST
Key Facts
- ℹ️Most common GI sarcoma
- ℹ️Excellent response to imatinib if KIT+
ICD-10: C49.A | Prevalence: nadir
Last updated: 11/9/2025