Overview
Mantle cell lymphoma has aggressive and indolent features, cyclin D1 overexpression.
Symptoms
- •Lymphadenopathy
- •GI symptoms
- •B symptoms
- •Splenomegaly
Diagnosis
- ✓Biopsy
- ✓IHC (cyclin D1+)
- ✓t(11;14)
- ✓PET-CT
Treatments
- →R-CHOP
- →Ibrutinib
- →Autologous stem cell transplant
- →BTK inhibitors
Risk Factors
⚠️Age >60
⚠️Male gender
Key Facts
- ℹ️Poor prognosis
- ℹ️MIPI score
ICD-10: C83.1 | Prevalence: nadir
Last updated: 11/9/2025