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Polycystic Kidney Disease

Genetic Kidney Disease

Overview

PKD is a genetic disorder with multiple cysts in kidneys leading to enlargement and failure.

Symptoms

  • Flank pain
  • Hematuria
  • Hypertension
  • Palpable kidneys

Diagnosis

  • Ultrasound (cysts)
  • CT/MRI
  • Genetic testing (PKD1/PKD2)

Treatments

  • Tolvaptan
  • BP control
  • Pain management
  • Dialysis/transplant

Risk Factors

⚠️Family history (AD)
⚠️PKD1 mutation

Key Facts

  • ℹ️ADPKD 90%
  • ℹ️ESRD by age 60 in 50%

ICD-10: Q61.2 | Prevalence: nadir

Last updated: 11/9/2025

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