Overview
Sickle cell disease is inherited hemoglobinopathy causing RBC sickling, vaso-occlusion, hemolysis.
Symptoms
- •Pain crises
- •Anemia
- •Dactylitis
- •Stroke
Diagnosis
- ✓HbS on electrophoresis
- ✓Newborn screening
- ✓CBC (low Hb, high retic)
Treatments
- →Hydroxyurea
- →Transfusion
- →Pain management
- →BMT (cure)
Risk Factors
⚠️African descent
⚠️Family history
Key Facts
- ℹ️1 in 365 African Americans
- ℹ️SCD complications: ACS, splenic sequestration
ICD-10: D57 | Prevalence: yaygın (endemik)
Last updated: 11/9/2025