Overview
Hemophilia is X-linked bleeding disorder due to factor VIII (A) or IX (B) deficiency.
Symptoms
- •Joint bleeding
- •Muscle hematoma
- •Prolonged bleeding
- •Spontaneous bleeds (severe)
Diagnosis
- ✓aPTT ↑
- ✓FVIII/IX activity <40%
- ✓Genetic testing
Treatments
- →FVIII/IX concentrate
- →Prophylaxis
- →Emicizumab (A)
Risk Factors
⚠️X-linked
⚠️Family history
Key Facts
- ℹ️1 in 5,000 males (A)
- ℹ️Inhibitors in 30%
ICD-10: D66-D68 | Prevalence: nadir
Last updated: 11/9/2025